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A Designated Member Review (DMR) or Designated Subcommittee Review (DSR) is a review of a protocol where a committee designates one or more members of the committee to review a decisionmaking process or a protocol or procedure, a review which would ordinarily require the full committee's review. Typically this pertains to IACUCs. In protocols of the National Institutes of Health (NIH) in the United States, 'Correct Conduct of Full-Committee and Designated-Member Protocol Reviews', there are two ways a procedure or protocol can be reviewed, according to PHS policy.〔(DMR & FCR, Office of Laboratory Animal Welfare - Topic Index, Protocol Review )〕 Sometimes a protocol or amendment to policies is submitted, which may not need to be considered at a full meeting. If everyone on the committee agrees, then the Chair or the committee can assign a person of knowledge and selected other member(s) to review the protocol and approve it or send it back to the full committee for discussion. A first step in such a process is for the chair to poll committee members to determine agreement for the DMR. If they agree, the DMR proceeds; if they do not agree, the DMR does not occur and it should be considered at a convened meeting by the complete committee.〔(Office of Laboratory Animal Welfare - Topic Index, Protocol Review )〕〔("Protocol review ... How is your IACUC doing?", AAALAC International Connection, Winter/Spring 2001 )〕〔(Guide for the Care and Use of Laboratory Animals (8th Edition, NRC 2011, National Academies Press), available for free download as a PDF in English, Chinese, Japanese, and Thai, and available as a hard copy )〕
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Contrasted with 'Full Committee Review' (FCR).〔(Office of Laboratory Animal Welfare (OLAW) ), Declining a DMR Request A request for a DMR can be declined by one or more IACUC members on the basis of reliability - that a DMR would compromise the reliability of the committee's conduct of its duties.〔Institutional Animal Care and Use Committee#Reliability〕 This could relate to the appearance of a 'workaround' to evade the legal duty to rigorously explore the 3Rs before approving a protocol. The Three Rs (3Rs) in relation to science are guiding principles for more ethical use of animals in testing. These were first described by W.M.S Russell and R.L. Burch in 1959.〔Russell, W.M.S. and Burch, R.L., (1959). ''The Principles of Humane Experimental Technique'', Methuen, London. ISBN 0900767782 ()〕 The 3Rs are - #Replacement which refers to the preferred use of non-animal methods over animal methods whenever it is possible to achieve the same scientific aims. #Reduction which refers to methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain more information from the same number of animals. #Refinement which refers to methods that alleviate or minimize potential pain, suffering or distress, and enhance animal welfare for the animals used. The 3Rs have a broader scope than simply encouraging alternatives to animal testing, but aim to improve animal welfare and scientific quality where the use of animals can not be avoided. In many countries, these 3Rs are now explicit in legislation governing animal use. == Bibliography == * William Russell and Rex Burch (1959) ''The Principles of Humane Experimental Technique''. London: Methuen. ISBN 978-0-900767-78-4 (paperback edition) 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Designated Member Review」の詳細全文を読む スポンサード リンク
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